Is Homocysteine a Risk Factor for Atherothrombotic Cardiovascular Disease?

Is homocysteine a risk factor for atherothrombotic cardiovascular disease?

1. Sipahi I, Tuzcu EM, Schoenhagen P, et al. Effects of normal, pre-hypertensive, and hypertensive blood pressure levels on progression of coronary atherosclerosis. J Am Coll Cardiol 2006;48:833–8. 2. Messerli FH, Mancia G, Conti CR, et al. Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous? Ann Intern Med 2006;144: 884 –9...

A Unique Risk Factor for Atherothrombotic Disease

In 1963, Kare Berg 1 immunized rabbits with human low density lipoprotein (LDL) and identified a genetic variation in the anti-LDL antibody response. He attributed this genetic variation to a unique fraction of LDL that he termed lipoprotein(a) (Lp[a]), and he believed that this trait was transmitted in an autosomal dominant fashion. Over the subsequent two decades, data obtained from several g...

Human T Lymphotropic Virus Type I (HTLV-I) is a Risk Factor for Coronary Artery Disease

Homocysteine: an emergent cardiovascular risk factor?

Cardiovascular disease is the leading cause of mortality and disability in the western world. In the last years, the accumulation of evidence coming from both retrospective and prospective clinical studies has led to an increased interest in the potential role of mild hyperhomocysteinemia as a major, independent risk factor for cardiovascular disease. The present paper reviews the position of h...

Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies.

BACKGROUND In epidemiological studies, within-person variability in plasma total homocysteine (tHcy) measurements may dilute the association of 'usual' levels of tHcy with risk of cardiovascular disease, referred to as 'regression dilution'. The aim of this report was to estimate the magnitude of regression dilution after varying intervals of follow-up. METHODS Regression dilution ratios (RDR...